The Utilization of Quetiapine in the Treatment of Bipolar Disorder

Quetiapine, also known for the trade name Seroquel and chemical name 2-[2-(4-dibenzo [b,f] [1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-ethanol fumarate, is an atypical antipsychotic, currently prescribed as a form of treatment for schizophrenia, bipolar disorder and depression. Quetiapine originally became available for treatment in 1997 in the United States and is still presently used as a form of first-line treatment (Riedel, Muller, Strassnig, Spellman, Severus, & Moller, 2007).

Don't use plagiarized sources. Get your custom essay on

“The Utilization of Quetiapine in the Treatment of Bipolar Disorder”

Get custom essay

For patients of bipolar disorder, Quetiapine has established efficacy in the treatment of acute mania and depression. Specifically, Quetiapine has been utilized as both a monotherapy and an adjunctive therapy for adults and adolescents with bipolar disorder (Dando & Keating, 2005). While the pathophysiology of bipolar disorder is quite ambiguous, the disorder is known for strong heritability, which has led to large bodies of research surrounding the genetic profile of the disorder. Specifically, the monoamine hypothesis and the hypothesis of low serotonergic function are cited as potential causes of depressive and manic episodes (Newberg, Catapano, Zarate, & Manji, 2008). The hypothesis states that abnormalities of the noradrenergic, dopaminergic, and serotonergic systems are present in bipolar disorder. In the pharmacological treatment of bipolar disorder, the dopamine D2 receptor is commonly blocked, in order to regulate dopaminergic systems. (Newberg et al., 2008). There is additional evidence of low levels of plasma in the GABAergic system and elevated levels in the Glutamatergic system. The pathophysiology of bipolar disorder is also evidently connected to intracellular cascades, and specifically, reductions of volume in the dorsolateral prefrontal cortex and low glial cell density (Newberg et al., 2008).

Quetiapine, in the treatment of bipolar disorder, is an antagonist of serotonin, dopamine, histamine, and norepinephrine. While the precise mechanism of action of quetiapine is unknown, the drug inhibits 5HT1A, 5HT2A, D1, D2, alpha 1, and alpha 2 receptors (Dando &Keating, 2005). Quetiapine is taken orally, and is mainly metabolized in the liver. The drug reaches steady-state plasma levels within two days of dosage, and the half-life is close to 6 hours. The drug is usually administered twice daily with an effective dosage of 400 to 800 milligrams per day (Dando & Keating, 2005). Quetiapine is well tolerated, however, patients may experience side effects such as weight gain, dry mouth, dizziness, sedation, constipation, vomiting, or headache. Quetiapine is highly efficacious in the reduction of manic and depressive symptoms in patients of Bipolar Disorder (Dando & Keating, 2005).

Did you like this example?

Cite this page

The Utilization of Quetiapine in The Treatment of Bipolar Disorder. (2019, Jul 29). Retrieved June 26, 2022 , from
https://studydriver.com/the-utilization-of-quetiapine-in-the-treatment-of-bipolar-disorder/

Save time with Studydriver!

Get in touch with our top writers for a non-plagiarized essays written to satisfy your needs

Get custom essay

Stuck on ideas? Struggling with a concept?

A professional writer will make a clear, mistake-free paper for you!

Get help with your assigment
Leave your email and we will send a sample to you.
Stop wasting your time searching for samples!
You can find a skilled professional who can write any paper for you.
Get unique paper

Hi!
I'm Chatbot Amy :)

I can help you save hours on your homework. Let's start by finding a writer.

Find Writer